Endocrine Abstracts

Background: Maturity onset diabetes of the young (MODY) has an estimated prevalence of 1–5% in the diabetic population, but misdiagnosis as type 1 or type 2 diabetes is common. It comprises a heterogeneous group of monogenic diseases characterized by primary dysfunction of β cell, young onset, autosomal dominant inheritance, without autoimmunity and without ketosis. Early diagnosis remains a challenge with important future implications, since it allows treatment opti...

Introduction: The Marine–Lenhart syndrome is a rare cause of hyperthyroidism that is associated with the simultaneous or sequential presence of characteristics related to Graves’ disease and toxic nodular or multinodular goiter. It’s validity as a disease is controversial and some authors believe that these are cases of hyperthyroidism where both etiologies coexist. The presence of hyperfunctioning nodules in Graves’ disease patients ranges between 0.8 and ...

Introduction: In chronic diseases a good psychological and behavioral adaptation is essential. Concerning diabetes the Insulin Delivery System (IDS) adopted tend to be an important factor of adaptation, global satisfaction and, above all, quality of life (QoL).Objectives: To analyze the QoL and IDS satisfaction and its relationship with psychopathological symptomatology in patients on continuous subcutaneous insulin infusion (CSII) therapy.<p class="...

Introduction: Combined central diabetes insipidus (DI) and cerebral salt wasting syndrome (CSW) is a rare clinical finding. However, when this happens, mortality is high due to delayed diagnosis and/or inadequate treatment.Case report: 42-year-old man referred to neurosurgery due to a non functional pituitary macroadenoma with bitemporal hemianopsia. He underwent partial ressection of the tumour on July 2nd 2015. On the following day of surgery he presen...

Introduction: In diabetes insipidus (DI) the serum sodium is often in the high normal range, required to provide the ongoing stimulation of thirst to replace the urinary losses. Marked hypernatremia can occur if a central lesion impairs both ADH release and thirst.Case report: A 57-year-old woman presented with dysuria, polyuria and fever. She was medicated with ciprofloxacin, however, she maintained symptoms, accompanied in the next day by nausea, vomit...

Introduction: CHARGE syndrome is a rare autossomal dominant genetic disorder with an estimated birth incidence of 1:10000. It affects multiple organ systems and can have a variable phenotypic expression.Case report: 34-years-old man, referred to Endocrinology in the context of bilateral gynecomastia. He had an acute corneal hydrops which was treated by ophthalmology. Physical examination showed short stature (149 cm), obesity (BMI 31.5 kg/m2),...

Introduction: Hypoglycemia is a major limiting factor in intensive glucose control in diabetes mellitus. Its incidence has been increasing with the demand for intensive therapy for the prevention of the diabetic chronic complications. There are few studies in our country regarding the evaluation of hypoglycemia in the emergency room (ER).Objective: To characterize severe hypoglycemia episodes and patient features in individuals admitted to the ER.<p ...

Introduction: Severe hypoglycemia is defined as an episode that requires the assistance of another person in order to correct it. Most of the costs associated with hypoglycemia in diabetes mellitus patients are the result of severe episodes, when treated by health care professionals. In our country there are few studies regarding the epidemiology of episodes of hypoglycemia evaluated in the pre-hospital care setting.Methods: We retrieved all episodes of ...

Introduction: Insulin neuritis is a rare form of presentation of diabetic neuropathy, usually associated with the sudden intensification of glucose control in individuals with long standing uncontrolled diabetes mellitus.Objectives: To report a case of insulin neuritis in a young male, few weeks after diagnosis and insulin therapy initiation.Clinical case: Male, 22 years old, previous history of excess weight until he was 19 years ...

Aim: To evaluate the serum levels of resistin and adiponectin, and the potential relationship between these adipokines, thyroid function, lipid profile, C-reactive protein (CRP) and homocysteine levels in patients with autoimmune thyroiditis (AIT) and subclinical hypothyroidism (SCH).Methods: patients with AIT (58 females; 47.7±16.7 years) were studied; 33 of them had also SCH. These patients were diagnosed by a positive result in an anti-peroxidase...